非常规衰老：衰老过程中的 γδ T 细胞、iNKT 细胞和 MAIT 细胞。
Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging.
机构信息
Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Nuffield Department of Medicine, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
出版信息
Semin Immunol. 2023 Sep;69:101816. doi: 10.1016/j.smim.2023.101816. Epub 2023 Aug 1.
Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T cells by their recognition of non-peptide ligands presented by non-polymorphic antigen presenting molecules and rapid effector functions that are pre-programmed during their development. Here we review current knowledge of the effect of age on unconventional T cells, from early life to old age, in both mice and humans. We then discuss the role of unconventional T cells in age-associated diseases and infections, highlighting the similarities between members of the unconventional T cell family in the context of aging.
非传统 T 细胞包括 γδ T 细胞、不变自然杀伤 T 细胞（iNKT）细胞和黏膜相关不变 T（MAIT）细胞，它们通过识别非多态性抗原呈递分子呈递的非肽配体和在发育过程中预先编程的快速效应功能与常规 T 细胞区分开来。在这里，我们综述了目前关于年龄对非传统 T 细胞的影响的知识，从生命早期到老年，包括小鼠和人类。然后，我们讨论了非传统 T 细胞在与年龄相关的疾病和感染中的作用，强调了非传统 T 细胞家族成员在衰老背景下的相似性。
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