Chouairy Camil J, Salloum Ali N, Ghazal George Y
Department of Pathology, St George Hospital University Medical Center, Achrafieh, Beirut, Lebanon.
J Med Liban. 2010 Apr-Jun;58(2):111-9.
Small cell (Neuroendocrine) carcinoma of the urinary bladder is a rare but highly aggressive malignancy. The neoplastic cells exhibit both neuroendocrine and epithelial differentiation. It is morphologically indistinguishable from the more common pulmonary small cell carcinoma. It can occur either in association with urothelial (transitional cell) carcinoma or in a pure form. Presenting signs and symptoms are non specific. Histologically, it can mimic poorly differentiated urothelial carcinoma and lymphoma. Muscle invasion is almost invariably present at diagnosis and mortality is mainly due to metastases rather than loco regional recurrence. The optimal therapeutic modality is still controversial. In this article, we report on two cases occurring in a pure form and we briefly review the published literature regarding the clinical presentation, morphology, differential diagnosis, prognosis and treatment.
膀胱小细胞（神经内分泌）癌是一种罕见但侵袭性很强的恶性肿瘤。肿瘤细胞同时表现出神经内分泌和上皮分化。在形态学上，它与更常见的肺小细胞癌无法区分。它既可以与尿路上皮（移行细胞）癌同时出现，也可以以纯形式出现。呈现的体征和症状不具有特异性。在组织学上，它可以模仿低分化尿路上皮癌和淋巴瘤。诊断时几乎总是存在肌层浸润，死亡率主要归因于转移而非局部区域复发。最佳治疗方式仍存在争议。在本文中，我们报告了两例纯形式的病例，并简要回顾了已发表的关于临床表现、形态学、鉴别诊断、预后和治疗的文献。
