Kartsounis L D, Crellin R F, Crewes H, Toone B K
National Hospital for Nervous Diseases, London.
Cortex. 1991 Mar;27(1):121-9. doi: 10.1016/s0010-9452(13)80275-4.
A case study of a 65 year old man is described with an eight-year history of progressive primary non-fluent aphasia accompanied by agrammatism, phonemic paraphasias and mild spelling dysgraphia. His naming ability, however, has remained at an exceptionally high level and there has been no evidence of impairment of word or sentence comprehension. Non-verbal skills and memory functions have also been preserved within the range of his very high premorbid level of abilities. Single photon emission computed tomography was consistent with bifrontal hypoperfusion. We argue that the selective language deficits in this patient are characteristic of dynamic aphasia and of other speech disturbances which are also known to be associated with left frontal lesions. The possible underlying pathology is discussed in the context of known degenerative disorders.
描述了一名65岁男性的病例研究，他有八年进行性原发性非流利性失语病史，伴有语法缺失、音素性错语和轻度拼写书写障碍。然而，他的命名能力一直保持在异常高的水平，并且没有单词或句子理解受损的证据。非语言技能和记忆功能也保持在其病前极高能力水平范围内。单光子发射计算机断层扫描与双侧额叶灌注不足一致。我们认为，该患者的选择性语言缺陷是动态失语以及其他已知与左侧额叶病变相关的言语障碍的特征。在已知退行性疾病的背景下讨论了可能的潜在病理。
