台湾台北市抗结核药物剂量不一致。

Inconsistent dosing of anti-tuberculosis drugs in Taipei, Taiwan.

机构信息

International Union Against Tuberculosis and Lung Disease, Paris, France.

出版信息

Int J Tuberc Lung Dis. 2010 Jul;14(7):878-83.

PMID:20550772

Abstract

SETTING

Taipei City, Taiwan.

OBJECTIVES

To evaluate prescribing practices for anti-tuberculosis drugs in the treatment of tuberculosis (TB).

METHOD

Medical audit of the medical charts of all patients notified and treated for TB in Taiwan in 2003 to determine the treatment regimens prescribed and to compare these with recommended dosages.

RESULTS

A total of 24 different anti-tuberculosis regimens were prescribed. Of 1700 patients notified, 1096 (64.5%) had their body weight recorded. Of 506 patients prescribed a three-drug fixed-dose combination (FDC), the dosage was adequate in 374 (73.9%), too low in 100 (19.8%) and too high in 32 (6.3%). Of 75 patients prescribed a two-drug FDC, the dosage was adequate in 57 (76.0%), too low in 15 (20.0%) and too high in 3 (4.0%). Of 481 patients prescribed rifampicin, the dosage was adequate in 302 (62.8%), too low in 152 (31.6%) and too high in 27 (5.6%). Of 451 patients prescribed isoniazid, the dosage was adequate in 396 (87.8%), too low in 29 (6.4%) and too high in 26 (5.8%).

CONCLUSION

The prescribing practices for anti-tuberculosis drugs were substandard and need improvement. These findings imply that the National TB Programme needs strengthening.

摘要

背景

中国台湾省台北市。

目的

评估 2003 年在台湾登记并接受治疗的结核病（TB）患者的抗结核药物处方实践，以确定所开的治疗方案，并与推荐剂量进行比较。

方法

对 2003 年台湾所有登记并接受治疗的结核病患者的病历进行医学审查，以确定所开的治疗方案，并与推荐剂量进行比较。

结果

共开出 24 种不同的抗结核方案。在 1700 名被通报的患者中，有 1096 名（64.5%）记录了体重。在 506 名服用三药固定剂量组合（FDC）的患者中，374 名（73.9%）剂量适当，100 名（19.8%）剂量过低，32 名（6.3%）剂量过高。在 75 名服用二药 FDC 的患者中，57 名（76.0%）剂量适当，15 名（20.0%）剂量过低，3 名（4.0%）剂量过高。在 481 名服用利福平的患者中，302 名（62.8%）剂量适当，152 名（31.6%）剂量过低，27 名（5.6%）剂量过高。在 451 名服用异烟肼的患者中，396 名（87.8%）剂量适当，29 名（6.4%）剂量过低，26 名（5.8%）剂量过高。