一种来自泽泻的新型三萜类抗乙型肝炎病毒活性化合物。
A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis.
作者信息
Jiang Zhi-Yong, Zhang Xue-Mei, Zhang Feng-Xue, Liu Ni, Zhao Fang, Zhou Jun, Chen Ji-Jun
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan, PR China.
出版信息
Planta Med. 2006 Aug;72(10):951-4. doi: 10.1055/s-2006-947178. Epub 2006 Jul 20.
A new triterpenoid named alisol O ( 1) was isolated from the rhizomes of Alisma orientalis, together with six known compounds: alisol A 24-acetate ( 2), 25-anhydroalisol A ( 3), 13 beta,17 beta-epoxyalisol A ( 4), alisol B 23-acetate ( 5), alisol F ( 6), and alisol F 24-acetate ( 7). Based on 1D and 2D-NMR data (HMQC, HMBC, COSY, ROESY), the structure of the new compound was deduced to be 11-dehydroxy-12-dehydroalisol F-24-acetate ( 1). Compounds 2 - 7 exhibited inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with IC (50) values of 2.3, 11.0, 15.4, 14.3, 0.6 and 7.7 microM, and on HBV e antigen (HBeAg) secretion with IC (50) values of 498.1, 17.6, 41.0, 19.9, 8.5 and 5.1 microM, respectively.
从泽泻的根茎中分离出一种名为泽泻醇O（1）的新三萜类化合物，以及六种已知化合物：泽泻醇A 24-乙酸酯（2）、25-脱水泽泻醇A（3）、13β，17β-环氧泽泻醇A（4）、泽泻醇B 23-乙酸酯（5）、泽泻醇F（6）和泽泻醇F 24-乙酸酯（7）。基于一维和二维核磁共振数据（HMQC、HMBC、COSY、ROESY），推断新化合物的结构为11-脱羟基-12-脱氢泽泻醇F-24-乙酸酯（1）。化合物2-7在体外对Hep G2.2.15细胞系的乙型肝炎病毒（HBV）表面抗原（HBsAg）分泌具有抑制活性，IC（50）值分别为2.3、11.0、15.4、14.3、0.6和7.7微摩尔，对HBV e抗原（HBeAg）分泌的IC（50）值分别为498.1、17.6、41.0、19.9、8.5和5.1微摩尔。
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