来自丝状真菌顶孢霉属菌株Acremonium sp. BCC 14080的酚苷

Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080.

作者信息

Bunyapaiboonsri Taridaporn, Yoiprommarat Seangaroon, Khonsanit Artit, Komwijit Somjit

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong 1, Klong Luang, Pathumthani, Thailand.

出版信息

J Nat Prod. 2008 May;71(5):891-4. doi: 10.1021/np070689m. Epub 2008 Mar 26.

DOI:10.1021/np070689m

PMID:18363379

Abstract

New phenolic mono- and digalactopyranosides (1 and 2), their aglycone KS-501a (3), and a new phenolic 4-O-methylglucopyranoside (4) were isolated from the filamentous fungus Acremonium sp. BCC 14080. Structures of these compounds were elucidated by extensive MS and NMR spectroscopic analyses. Compound 1 displayed anti-HSV-1 activity with an IC(50) value of 7.2 microM. Compound 3 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 9.9 microM.

摘要

从丝状真菌顶孢霉属Acremonium sp. BCC 14080中分离得到了新的酚类单半乳糖吡喃糖苷和双半乳糖吡喃糖苷（1和2）、它们的苷元KS-501a（3）以及一种新的酚类4-O-甲基葡萄糖吡喃糖苷（4）。通过广泛的质谱和核磁共振光谱分析阐明了这些化合物的结构。化合物1表现出抗单纯疱疹病毒1型（HSV-1）活性，IC50值为7.2微摩尔/升。化合物3对恶性疟原虫K1表现出活性，IC50值为9.9微摩尔/升。