使用顺序硫醇-烯/硫醇-炔光反应合成环状、多价的 Arg-Gly-Asp。
Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol-ene/thiol-yne photoreactions.
机构信息
Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO 80309, USA.
出版信息
Chem Commun (Camb). 2010 Aug 21;46(31):5781-3. doi: 10.1039/c0cc01292k. Epub 2010 Jun 15.
Abstract
A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated reactions.
摘要
现已开发出一种独特的多价环肽形成方法。该方法利用树脂上肽环化的光引发硫醇-烯点击反应和随后使用硫醇-炔光化学的聚集来实现。这两个反应都利用天然半胱氨酸氨基酸上的巯基来参与巯基介导的反应。
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