Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL 61801, USA.
Biomacromolecules. 2012 Nov 12;13(11):3456-62. doi: 10.1021/bm301333w. Epub 2012 Oct 26.
Synthesis of polyesters bearing pendant amine groups with controlled molecular weights and narrow molecular weight distributions was achieved through ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione, an O-carboxyanhydride derived from tyrosine, followed by thiol-yne "click" photochemistry with 2-aminoethanethiol hydrochloride. This class of biodegradable polymers displayed excellent cell penetration and gene delivery properties with low toxicities.
通过对酪氨酸衍生的 O-羧基酸酐 5-(4-(丙-2-炔-1-基氧基)苄基)-1,3-二氧戊环-2,4-二酮进行开环聚合，然后与 2-氨基乙硫醇盐酸盐进行硫醇-炔点击光化学反应，合成了具有可控分子量和较窄分子量分布的带有侧链伯胺基团的聚酯。这类可生物降解的聚合物具有良好的细胞穿透性和基因传递性能，且毒性较低。
