Silverstein E, Friedland J, Setton C
Isr J Med Sci. 1978 Mar;14(3):314-8.
Low angiotensin-converting enzyme (ACE) activity was found in rat and mouse peritoneal macrophages, in rat and rabbit pulmonary alveolar macrophages, in cultured mouse peritoneal macrophages stimulated i.p. for four days by thioglycollate, and in rabbit pulmonary alveolar macrophages stimulated in culture by 0.1 to 100 microgram/ml Salmonella typhosa endotoxin for four days. Rat subcutaneous Freund's adjuvant granulomas induced with Mycobacterium butyricum or M. tuberculosis H37 Ra contianed low ACE activity which was generally lower than that present in control tissues. Increased ACE activity in sarcoidosis and Gaucher's disease lesions does not reflect a universally high synthesis of ACE in mammalian macrophages or granulomas, but may be due to specific mechanisms.
在大鼠和小鼠的腹膜巨噬细胞、大鼠和兔的肺泡巨噬细胞、经腹腔注射巯基乙酸刺激四天的培养小鼠腹膜巨噬细胞以及在培养中经0.1至100微克/毫升伤寒沙门氏菌内毒素刺激四天的兔肺泡巨噬细胞中，发现血管紧张素转换酶（ACE）活性较低。用丁酸分枝杆菌或结核分枝杆菌H37 Ra诱导的大鼠皮下弗氏佐剂肉芽肿含有低ACE活性，其通常低于对照组织中的活性。结节病和戈谢病病变中ACE活性的增加并不反映哺乳动物巨噬细胞或肉芽肿中普遍存在的ACE高合成，而可能是由于特定机制。
