Bozhko G Kh, Boĭko T P, Voloshin P V
Fiziol Zh (1978). 1991 Jan-Feb;37(1):49-53.
Acetaldehyde alone and in combination with acute and chronic ethanol intoxication has been studied for its effect on the concentration of epinephrine and norepinephrine in different brain areas, in the heart muscle, in adrenals and blood plasma of rats. Acetaldehyde is shown to enhance the epinephrine and norepinephrine levels in the brain areas which are non-specific for neuromediation of the mentioned catecholamines. The joint administration of acetaldehyde and ethanol increased the epinephrine concentration in adrenals probably due to the effect of acetaldehyde. On the contrary, the norepinephrine concentration in the heart decreased because of the action of ethanol. The authors' data show that acetaldehyde becomes an inductor of the mechanisms of hormone-mediator dissociation, thus altering the functions of vegetative-adrenal system. The results of the investigation support the hypothesis that acetaldehyde plays a significant role among pathogenic factors of ethanol intoxication, since it changes in a special way the catecholamine concentration in the brain and in peripheral tissues.
已经对单独的乙醛以及与急性和慢性乙醇中毒相结合的情况进行了研究，以探讨其对大鼠不同脑区、心肌、肾上腺和血浆中肾上腺素和去甲肾上腺素浓度的影响。结果表明，乙醛会提高那些对上述儿茶酚胺的神经调节不具有特异性的脑区中的肾上腺素和去甲肾上腺素水平。乙醛与乙醇联合给药可能由于乙醛的作用而增加了肾上腺中的肾上腺素浓度。相反，由于乙醇的作用，心脏中的去甲肾上腺素浓度降低。作者的数据表明，乙醛成为激素 - 介质解离机制的诱导剂，从而改变了植物性 - 肾上腺系统的功能。研究结果支持了这样的假设，即乙醛在乙醇中毒的致病因素中起重要作用，因为它以特殊方式改变了大脑和外周组织中的儿茶酚胺浓度。
