Department of Oto-rhino-laryngology, Head and Neck Surgery, Rigshospitalet, University of Copenhagen, Denmark.
APMIS. 2010 Jun;118(6-7):510-9. doi: 10.1111/j.1600-0463.2010.02624.x.
Over the last 20 years, there has been increasing awareness of a subset of squamous cell carcinomas of the head and neck (HNSCC), i.e. HPV-positive HNSCC. These cancers seem to differ somewhat from HPV-negative HNSCC. Patients with HPV-positive HNSCC tend to be younger and have a lower intake of tobacco and alcohol. Distinct molecular profiles separate them from HPV-negative cancers and show similarities with HPV-positive cervical SCC. There is evidence that HPV-positive HNSCC is a sexually transmitted disease. Patients with HPV-positive HNSCC are often diagnosed at a late stage with large cystic lymph nodes in the neck. HPV-positive HNSCC show an affinity for the oropharynx, especially the tonsils and the base of the tongue, and tend to show low differentiation histopathologically. There is a better prognosis regardless of the treatment regimen for HPV-positive HNSCC compared with HPV-negative HNSCC, and this seems to be related to the immune system. Whether the new vaccines for HPV will protect not only against cervical cancer but also against HPV-positive HNSCC remains unknown.
在过去的 20 年中，人们越来越意识到头颈部鳞状细胞癌（HNSCC）的一个亚组，即 HPV 阳性 HNSCC。这些癌症似乎与 HPV 阴性 HNSCC 有些不同。HPV 阳性 HNSCC 患者往往更年轻，吸烟和饮酒量较低。独特的分子谱将它们与 HPV 阴性癌症区分开来，并与 HPV 阳性宫颈癌 SCC 具有相似性。有证据表明 HPV 阳性 HNSCC 是一种性传播疾病。HPV 阳性 HNSCC 患者通常在晚期被诊断出，颈部有大的囊性淋巴结。HPV 阳性 HNSCC 对口咽，特别是扁桃体和舌根部有亲和力，并且往往在组织病理学上显示低分化。与 HPV 阴性 HNSCC 相比，HPV 阳性 HNSCC 的预后无论治疗方案如何都更好，这似乎与免疫系统有关。新的 HPV 疫苗是否不仅能预防宫颈癌，还能预防 HPV 阳性 HNSCC，目前尚不清楚。
