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人乳头瘤病毒与口腔鳞状细胞癌的关联：癌症患者对人乳头瘤病毒16型筛查的迫切需求。

Association of Human Papilloma Virus in Oral Squamous Cell Carcinoma: An Alarming Need for Human Papillomavirus 16 Screening in Cancer Patients.

作者信息

Venkatesh Arvind, Elengkumaran S, Ravindran C, Malathi N

机构信息

Senior Lecturer, Department of Oral and Maxillofacial Surgery, Madha Dental College, Kundrathur, Chennai, India.

Associate Professor, Department of Oral and Maxillofacial Surgery, Sri Ramachandra Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

出版信息

J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1224-S1227. doi: 10.4103/jpbs.jpbs_370_21. Epub 2021 Nov 10.

DOI:10.4103/jpbs.jpbs_370_21
PMID:35017960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8686889/
Abstract

BACKGROUND

The percentage of cancers of the tongue and palatine tonsils has continued to increase by 2%-4% among younger men. This increased prevalence of a subsection of oropharyngeal carcinoma can be associated with human papillomavirus (HPV). Among the head-and-neck cancers, a strong association with HPV infection is evident with oropharyngeal cancers, particularly tonsillar and basal tongue cancers.

OBJECTIVES

Oral carcinoma, with an overall incidence of 16.1 adults per 100,000, is one of the leading malignancies worldwide, presenting a noticeable geographic variation in its distribution. Squamous cell carcinoma (SCC) being the most common of all oral malignancies, the objective of the study is to detect the HPV antigen p16 over-expression in patients with oral SCC using immunohistochemistry (IHC).

MATERIALS AND METHODS

Oral SCC (OSCC) diagnosed formalin-fixed-paraffin embedded blocks were processed for IHC.

RESULTS

Out of 50 cases, 3 were deferred due to insufficient tumor sample and 2/47 cases were p16 positive and the site was the lateral border of the tongue.

CONCLUSION

The HPV antigen overexpression in patients with OSCC was investigated to detect the incidence of HPV in SCC of oral cavity. P16 was used as a marker for the detection of OSCC using IHC in HPV-induced OSCC. Positives were detected thus concluding the significance of studying HPV expression during diagnosis.

摘要

背景

在年轻男性中，舌癌和腭扁桃体癌的比例持续以2%-4%的速度上升。口咽癌这一亚组患病率的增加可能与人乳头瘤病毒（HPV）有关。在头颈癌中，口咽癌，尤其是扁桃体癌和舌根癌与HPV感染有明显的强关联。

目的

口腔癌的总体发病率为每10万成年人中有16.1例，是全球主要的恶性肿瘤之一，其分布存在明显的地理差异。鳞状细胞癌（SCC）是所有口腔恶性肿瘤中最常见的，本研究的目的是使用免疫组织化学（IHC）检测口腔SCC患者中HPV抗原p16的过表达。

材料与方法

对经福尔马林固定石蜡包埋块诊断的口腔SCC进行IHC处理。

结果

50例中，3例因肿瘤样本不足而延期，47例中有2例p16呈阳性，部位为舌侧缘。

结论

研究口腔SCC患者中HPV抗原的过表达，以检测口腔SCC中HPV的发生率。在HPV诱导的口腔SCC中，p16被用作通过IHC检测口腔SCC 的标志物。检测到阳性结果，从而得出在诊断过程中研究HPV表达的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/7f00d94cca9f/JPBS-13-1224-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/a252d3c1640b/JPBS-13-1224-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/83c77b67909c/JPBS-13-1224-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/7f00d94cca9f/JPBS-13-1224-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/a252d3c1640b/JPBS-13-1224-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/83c77b67909c/JPBS-13-1224-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0526/8686889/7f00d94cca9f/JPBS-13-1224-g003.jpg

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