Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, Cordoba University, 14014 Cordoba, Spain.
Vet J. 2010 Jul;185(1):83-7. doi: 10.1016/j.tvjl.2010.04.018. Epub 2010 May 31.
Concentrations of the acute phase proteins haptoglobin (Hp) and C-reactive protein (CRP) were measured in the serum, saliva and meat juice of pigs experimentally infected with a porcine reproductive and respiratory syndrome virus (PRRSv) field isolate. Sixteen PRRSv-free pigs were inoculated IM, killed in groups of four at 7, 14, 21 and 24 days post-inoculation (dpi), and samples of blood, saliva and diaphragmatic muscle were collected. Four non-infected controls were killed at 24 dpi. Significant differences in lung lesions were found between PRRSv-inoculated animals and controls. Changes in the concentrations of Hp and CRP in serum, saliva and meat juice samples were similar, peaking at 21 dpi. The correlations found suggest that the measurement of Hp and CRP in saliva and meat juice could serve as complementary, or possibly alternative, biomarkers of pig herd-health.
检测了感染猪繁殖与呼吸综合征病毒（PRRSv）田间分离株的猪的血清、唾液和肉汁中的急性相蛋白结合珠蛋白（Hp）和 C 反应蛋白（CRP）的浓度。将 16 头 PRRSv 阴性猪肌内接种，在接种后 7、14、21 和 24 天（dpi）分 4 组杀死，并采集血液、唾液和横膈膜样本。4 头非感染对照猪在 24 dpi 处死。PRRSv 感染动物和对照组之间的肺部病变存在显著差异。血清、唾液和肉汁样本中 Hp 和 CRP 浓度的变化相似，在 21 dpi 时达到峰值。发现的相关性表明，唾液和肉汁中 Hp 和 CRP 的测量可以作为猪群健康的补充，或者可能是替代的生物标志物。
