Unité Interactions Hôte-Agents Pathogènes, Département de Microbiologie, Institut de recherche biomédicale des Armées, La Tronche, France.
Trends Mol Med. 2010 Jul;16(7):303-12. doi: 10.1016/j.molmed.2010.04.006. Epub 2010 Jun 1.
Lung immune responses control pathogens while avoiding detrimental inflammation. The dynamics of lung homeostasis are not fully understood. Primary antimicrobial defenses are orchestrated by epithelial cells (ECs), interacting in close association with dendritic cells (DCs) and other innate immune cells. However, microbes, such as Bacillus anthracis use host cellular machinery, including DC-migratory capacity to reach the draining lymph nodes where they germinate and produce toxins that disrupt protective immunity leading to death. Here, we describe the immunobiology of major lung cell subsets and their cellular synapses, to reveal the dynamics of B. anthracis infection and its effects on lung immune mechanisms. Vaccines strategies that mobilize protective mucosal and systemic immunity against this deadly microbe are highlighted.
肺部免疫反应在控制病原体的同时避免有害炎症。肺部动态平衡的机制尚不完全清楚。初级抗菌防御由上皮细胞 (EC) 协调，与树突状细胞 (DC) 和其他先天免疫细胞密切相互作用。然而，细菌，如炭疽芽孢杆菌利用宿主细胞机制，包括 DC 迁移能力，到达引流淋巴结，在那里它们发芽并产生毒素，破坏保护性免疫，导致死亡。在这里，我们描述了主要肺细胞亚群及其细胞突触的免疫生物学，以揭示炭疽杆菌感染的动态及其对肺部免疫机制的影响。强调了针对这种致命微生物动员保护性黏膜和全身免疫的疫苗策略。
