Tournier Jean-Nicolas, Mohamadzadeh Mansour
Centre de Recherches du Service de Santédes Armées, Unité Interactions Hôte-Pathogéne, La Tronche, France.
Expert Rev Vaccines. 2008 May;7(4):457-66. doi: 10.1586/14760584.7.4.457.
The lung is a vital organ devoted mainly to gas exchange with an external environment that may be contaminated with various life-threatening pathogens and inert particles. Lung immunity must be permanently balanced between costimulatory and coinhibitory signals, thus controlling potential pathogens while avoiding detrimental inflammation. The lung harbors macrophages and dendritic cells (myeloid and plasmacytoid), which orchestrate the primary defense against microbial invaders. During an infection involving host-microbial synapses, microbes either escape by using host cell physiology or are eliminated by a robust immune response. We thus focus on the dynamics of such cellular interactions within the lung and stress the critical role played by airway epithelial cells in modulating immunity.
肺是一个主要致力于与外部环境进行气体交换的重要器官，外部环境可能被各种危及生命的病原体和惰性颗粒污染。肺免疫必须在共刺激和共抑制信号之间永久保持平衡，从而控制潜在病原体，同时避免有害炎症。肺中存在巨噬细胞和树突状细胞（髓样和浆细胞样），它们协调针对微生物入侵者的主要防御。在涉及宿主-微生物突触的感染过程中，微生物要么利用宿主细胞生理机制逃脱，要么被强大的免疫反应清除。因此，我们关注肺内这种细胞相互作用的动态，并强调气道上皮细胞在调节免疫中所起的关键作用。
