Styrna J, Imai H T, Moriwaki K
Department of Genetics and Evolution, Jagiellonian University, Krakow, Poland.
Genet Res. 1991 Apr;57(2):195-9. doi: 10.1017/s0016672300029268.
Two congenic lines of mice, one with a partial deletion of the Y chromosome, differ in the percentage of spermatozoa with abnormal heads: B10.BR/SgSn males give 22.6% and B10.BR-Ydel/Ms males give 64.2% abnormal sperm. The F1s resulting from crosses of B10.BR/SgSn males with females of five common inbred strains exhibited significantly lower levels of abnormal sperm than the parental strains, as opposed to F1 hybrids sired by B10.BR-Ydel/Ms mutant males, where very high levels of abnormal spermatozoa were found. About 30% of abnormal spermatozoa, produced by males with deletion on the Y chromosome, were characterized by a flat acrosomal cap. This class of abnormality was never observed in non-mutant males, suggesting a mutant-specific defect. These results demonstrate the important role of the Y chromosome in spermatogenesis.
两种近交系小鼠，一种Y染色体有部分缺失，其头部异常的精子百分比存在差异：B10.BR/SgSn雄性小鼠产生的异常精子占22.6%，而B10.BR-Ydel/Ms雄性小鼠产生的异常精子占64.2%。B10.BR/SgSn雄性小鼠与五个常见近交系雌性交配所产生的F1代，其异常精子水平显著低于亲本品系，与之相反，由B10.BR-Ydel/Ms突变雄性小鼠产生的F1代杂种中，发现有非常高比例的异常精子。Y染色体缺失的雄性小鼠产生的异常精子中，约30%的特征是顶体帽扁平。在非突变雄性小鼠中从未观察到这类异常，提示这是一种突变特异性缺陷。这些结果证明了Y染色体在精子发生中的重要作用。
