Department of Medical Biopathology, University of Athens Medical School, Athens, Greece.
In Vivo. 2010 May-Jun;24(3):325-8.
BACKGROUND/AIM: The need for sensitive biological markers to detect and prove recent drinking has been the focus of many research groups. The aim of our study was to investigate the alterations of biological markers in a population of alcohol dependent individuals during the detoxification period.
Fifty-two alcohol-dependent individuals were admitted for alcohol detoxification on an inpatient basis. Carbohydrate-deficient transferrin (CDT), gamma-glutamyl transpeptidase (gamma-GT), interleukin-6 (IL-6), mean corpuscular volume (MCV), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) were obtained at admission and on a 15-day basis. Comparisons between measures were made with t-test.
All biochemical parameters associated with alcoholism, with the exception of MCV, were statistically significantly decreased during the detoxification process (p<0.05).
CDT is an excellent marker of alcohol overconsumption during evaluation, as well as during the detoxification treatment. IL-6 could serve as an additional marker to CDT, a point needing further investigation.
背景/目的：寻找灵敏的生物标志物来检测和证明近期饮酒情况一直是许多研究小组关注的焦点。我们的研究旨在探讨酒精依赖个体在解毒期间生物标志物的变化。
52 名酒精依赖患者入院接受住院酒精解毒治疗。入院时和入院后第 15 天分别检测血清转铁蛋白缺乏（CDT）、γ-谷氨酰转肽酶（γ-GT）、白细胞介素 6（IL-6）、平均红细胞体积（MCV）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和碱性磷酸酶（ALP）。采用 t 检验比较各项指标。
除 MCV 外，所有与酒精中毒相关的生化参数在解毒过程中均呈统计学显著降低（p<0.05）。
CDT 是评估和解毒治疗期间酒精过量的优秀标志物。IL-6 可以作为 CDT 的附加标志物，这一点需要进一步研究。
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