• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Thermolysin: a peptide forming enzyme.

作者信息

Reddy A V

机构信息

Vittal Mallya Scientific Research Foundation, Bangalore, India.

出版信息

Indian J Biochem Biophys. 1991 Feb;28(1):10-5.

PMID:2055595
Abstract

Thermolysin, a thermostable endopeptidase, is recognised as a potential peptide bond forming enzyme. The importance of structural properties and its stereospecific nature towards peptide bond formation is described. Thermolysin's use in the keystep of the preparation of an artificial sweetener 'aspartame' is highlighted.

摘要

相似文献

1
Thermolysin: a peptide forming enzyme.
Indian J Biochem Biophys. 1991 Feb;28(1):10-5.
2
Enhancement of the aspartame precursor synthetic activity of an organic solvent-stable protease.提高有机溶剂稳定蛋白酶的阿斯巴甜前体合成活性。
Protein Eng Des Sel. 2010 Mar;23(3):147-52. doi: 10.1093/protein/gzp086. Epub 2010 Jan 18.
3
[Renaturation of bacterial metalloproteinases].
Biokhimiia. 1993 Jun;58(6):913-20.
4
Thermostable neutral protease resembling thermolysin derived from Bacillus brevis MIB001.
Biosci Biotechnol Biochem. 1998 May;62(5):1028-30. doi: 10.1271/bbb.62.1028.
5
[Analysis of the structure of Bacillus brevis neutral proteinase and its biosynthesis in Bacillus subtilis cells].
Mol Biol (Mosk). 1990 Sep-Oct;24(5):1381-92.
6
The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential.热解素酶家族(M4):治疗及生物技术潜力
Chem Biol Drug Des. 2009 Jan;73(1):7-16. doi: 10.1111/j.1747-0285.2008.00757.x.
7
Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.定点诱变证据表明,嗜热菌蛋白酶的精氨酸203和中性内肽酶(肾肽酶)的精氨酸717在底物水解和抑制剂结合中起同等关键作用。
Biochemistry. 1997 Nov 11;36(45):13938-45. doi: 10.1021/bi9712495.
8
Conformational dynamics of free and catalytically active thermolysin are indistinguishable by hydrogen/deuterium exchange mass spectrometry.通过氢/氘交换质谱法无法区分游离的和具有催化活性的嗜热菌蛋白酶的构象动力学。
Biochemistry. 2008 Jun 17;47(24):6342-51. doi: 10.1021/bi800463q. Epub 2008 May 22.
9
Purification and characterization of a neutral zinc endopeptidase secreted by Flavobacterium meningosepticum.脑膜炎败血黄杆菌分泌的一种中性锌内肽酶的纯化与特性分析
Arch Biochem Biophys. 1994 May 15;311(1):127-32. doi: 10.1006/abbi.1994.1217.
10
Comparison of the subsite specificity of the mammalian neutral endopeptidase 24.11 (enkephalinase) to the bacterial neutral endopeptidase thermolysin.
J Biol Chem. 1986 May 15;261(14):6433-7.

引用本文的文献

1
Outliers in SAR and QSAR: is unusual binding mode a possible source of outliers?SAR和QSAR中的异常值:异常的结合模式可能是异常值的一个来源吗?
J Comput Aided Mol Des. 2007 Jan-Mar;21(1-3):63-86. doi: 10.1007/s10822-007-9106-2. Epub 2007 Mar 3.