Yang Rui, Zhang Xiaoping, Wei Wenning, Hong Mei, Yang Yan, Hu Yu
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2010 Jun;30(3):312-7. doi: 10.1007/s11596-010-0348-1. Epub 2010 Jun 17.
This study examined the changes of activities of vitamin K-dependent clotting factors (VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage. Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed. Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects. The results showed that the average activities of VKDCFs were decreased in the patients in comparison to the control subjects and significantly increased after treatment of these patients with vitamin K and blood products. Multivariate regression analysis indicated that decreased activity of VKDCF was not an independent risk factor for bleeding disorders owing to deficiency or metabolic disturbance of vitamin K. It was concluded that acquired deficiency of VKDCF occurs under a variety of pathologic conditions and is closely associated with hemorrhagic events. Administration of vitamin K and transfusion of blood products containing high concentrations of VKDCFs helps alleviate the hemorrhagic diseases.
本研究检测了各种病理状态下维生素K依赖凝血因子（VKDCF）的活性变化，并探讨了获得性VKDCF缺乏与出血之间的关系。回顾性分析了35例诊断为获得性VKDCF缺乏患者的临床资料。检测了这些患者及41名对照者的内源性和外源性凝血途径相关凝血因子。结果显示，与对照者相比，患者的VKDCF平均活性降低，在给予这些患者维生素K和血液制品治疗后显著升高。多因素回归分析表明，VKDCF活性降低并非维生素K缺乏或代谢紊乱所致出血性疾病的独立危险因素。得出结论：获得性VKDCF缺乏发生于多种病理状态下，且与出血事件密切相关。给予维生素K及输注含高浓度VKDCF的血液制品有助于缓解出血性疾病。
