Di Biase M, Tritto M, Pitzalis M V, Favale S, Rizzon P
Division of Cardiology, University of Bari, Italy.
Int J Cardiol. 1991 Mar;30(3):329-33. doi: 10.1016/0167-5273(91)90011-d.
L-propionylcarnitine, a short-chain acylcarnitine, has been shown in experimental studies to induce, during acidic and hypoxic conditions, some electrophysiological changes such as an increase of duration of the action potential and of the effective refractory period. In this study, the acute electrophysiological effects of intravenous L-propionylcarnitine (30 mg/kg in 3 min) were studied in 12 subjects with estimated normal function of the sinus node and normal parameters for atrioventricular conduction. Statistically significant changes were observed 2 min after infusion. The sinus cycle length shortened (866 +/- 138 vs 818 +/- 124 msec, P less than 0.05) while refractory periods of the atrioventricular node increased (effective by 30-50 msec in four cases; functional from 425 +/- 52 to 436 +/- 55 msec, P less than 0.05). Sinuatrial conduction time, atrial refractory periods, infranodal conduction, bundle branch, His-Purkinje system and ventricular refractoriness were unchanged. Systolic and diastolic blood pressure were also unchanged. Because of the limited effects on electrophysiological parameters, L-propionylcarnitine should be used as a metabolic drug even in patients with mild disturbances of conduction.
左旋丙酰肉碱是一种短链酰基肉碱，实验研究表明，在酸性和缺氧条件下，它会引发一些电生理变化，比如动作电位持续时间和有效不应期增加。在本研究中，对12名窦房结功能估计正常且房室传导参数正常的受试者，研究了静脉注射左旋丙酰肉碱（3分钟内注射30毫克/千克）的急性电生理效应。输注后2分钟观察到有统计学意义的变化。窦性周期长度缩短（866±138毫秒对818±124毫秒，P<0.05），而房室结的不应期增加（4例有效增加30 - 50毫秒；功能不应期从425±52毫秒增至436±55毫秒，P<0.05）。窦房传导时间、心房不应期、结下传导、束支、希氏 - 浦肯野系统及心室不应期均未改变。收缩压和舒张压也未改变。由于对电生理参数的影响有限，即使在轻度传导障碍患者中，左旋丙酰肉碱也应作为一种代谢药物使用。
