CYP2E1 PstI/RsaI 多态性与结直肠癌风险：荟萃分析。
CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis.
机构信息
Department of Respiration, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
出版信息
World J Gastroenterol. 2010 Jun 21;16(23):2949-53. doi: 10.3748/wjg.v16.i23.2949.
AIM
To clarify the association between CYP2E1 PstI/RsaI polymorphism and susceptibility to colorectal cancer.
METHODS
A meta-analysis based on 10 eligible case-control studies involving 4979 cases and 6012 controls was carried out to summarize the data on the association between CYP2E1 RsaI/PstI polymorphism and colorectal cancer risk.
RESULTS
In comparison of the homozygote c2c2 and c2 carriers (c1c2 + c2c2) and the homozygous wild-type genotype (c1c1), no association was found between CYP2E1 RsaI/PstI polymorphism and colorectal cancer risk [odds ratio (OR) = 1.24 (95% CI: 0.93-1.66) for c2c2; OR = 1.02 (95% CI: 0.88-1.19) for c2 carriers]. In stratified analysis, Caucasians with c2c2 homozygote appeared to have an increased risk of colorectal cancer (OR = 2.67, 95% CI: 1.03-6.89, P = 0.043), no significant associations were found in other groups.
CONCLUSION
c2c2 homozygote of CYP2E1 PstI/RsaI polymorphism may be associated with the increased risk of colorectal cancer in Caucasians, which needs further investigations.
目的
阐明 CYP2E1 PstI/RsaI 多态性与结直肠癌易感性的关系。
方法
基于 10 项合格的病例对照研究，对 CYP2E1 RsaI/PstI 多态性与结直肠癌风险之间的关联数据进行汇总分析，共纳入 4979 例病例和 6012 例对照。
结果
与 CYP2E1 RsaI/PstI 多态性的纯合子 c2c2 和 c2 携带者（c1c2+c2c2）与纯合野生型基因型（c1c1）相比，结直肠癌风险无显著相关性[比值比（OR）=1.24（95%可信区间：0.93-1.66）用于 c2c2；OR=1.02（95%CI：0.88-1.19）用于 c2 携带者]。分层分析显示，白种人 c2c2 纯合子患结直肠癌的风险似乎增加（OR=2.67，95%可信区间：1.03-6.89，P=0.043），而其他组无显著相关性。
结论
CYP2E1 PstI/RsaI 多态性的 c2c2 纯合子可能与白种人结直肠癌风险增加相关，这需要进一步研究。
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