Zhuo Xianlu, Song Jue, Liao Jian, Zhou Wei, Ye Huiping, Li Qi, Xiang Zhaolan, Zhang Xueyuan
Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing Affiliated Hospital of Guiyang Medical University, Guiyang Post-doctoral Scientific Research Station, Chongqing Cancer Institute, Chongqing, China.
Medicine (Baltimore). 2016 Oct;95(43):e5156. doi: 10.1097/MD.0000000000005156.
Previous reports showed that CYP2E1 RsaI/PstI polymorphism may be a risk factor for cancers. Published meta-analyses in 2010 and 2011, respectively, on the relationship of CYP2E1 RsaI/PstI polymorphisms with the susceptibility to head and neck carcinoma (HNC) have generated inconsistent results. Thus, this study aimed to conduct an updated meta-analysis involving published studies up to Nov 2015 to get a more confidential result.
Eligible studies up to Nov 2015 were retrieved and screened. Data were extracted and a quantitative meta-analysis was conducted. Subgroup analyses on ethnicity, source of controls, sample size, genotyping method, smoking status, and drinking status were also performed.
Forty-one publications including a total of 43 case-control studies were selected for analysis. The overall data under a homozygote comparison model indicated a significant association of CYP2E1 RsaI/PstI polymorphisms with HNC risk (c2c2 vs c1c1: odds ratio [OR] = 1.97; 95% confidence interval [CI] = 1.53-2.53). Similar results were observed in the Asian subgroup (c2c2 vs c1c1: OR = 1.98; 95%CI = 1.51-2.60; c2 vs c1: OR = 1.20; 95%CI = 1.03-1.39) and mixed population (c2 vs c1: OR = 1.41; 95%CI = 1.06-1.86) when the data were stratified by ethnicities. Interestingly, increased cancer risk only was shown among never-smokers (c2c2+c1c2 vs c1c1: OR = 1.44; 95%CI = 1.05-1.98) but not ever-smokers.
CYP2E1 RsaI/PstI polymorphisms may modify the susceptibility to HNC, particularly among Asians, mixed population, and never-smokers. Future large and well-designed studies are needed to verify this conclusion.
既往报告显示，CYP2E1 RsaI/PstI基因多态性可能是癌症的一个风险因素。2010年和2011年分别发表的关于CYP2E1 RsaI/PstI基因多态性与头颈癌（HNC）易感性关系的荟萃分析结果并不一致。因此，本研究旨在进行一项更新的荟萃分析，纳入截至2015年11月发表的研究，以获得更可靠的结果。
检索并筛选截至2015年11月的符合条件的研究。提取数据并进行定量荟萃分析。还对种族、对照来源、样本量、基因分型方法、吸烟状况和饮酒状况进行了亚组分析。
共选择41篇文献，包括43项病例对照研究进行分析。纯合子比较模型下的总体数据表明，CYP2E1 RsaI/PstI基因多态性与HNC风险显著相关（c2c2与c1c1比较：比值比[OR]=1.97；95%置信区间[CI]=1.53-2.53）。按种族分层时，在亚洲亚组（c2c2与c1c1比较：OR=1.98；95%CI=1.51-2.60；c2与c1比较：OR=1.20；95%CI=1.03-1.39）和混合人群（c2与c1比较：OR=1.41；95%CI=1.06-1.86）中观察到类似结果。有趣的是，仅从不吸烟者中显示出癌症风险增加（c2c2+c1c2与c1c1比较：OR=1.44；95%CI=1.05-1.98），而曾经吸烟者未显示。
CYP2E1 RsaI/PstI基因多态性可能会改变对HNC的易感性，尤其是在亚洲人、混合人群和从不吸烟者中。未来需要进行大规模且设计良好的研究来验证这一结论。
