CYP2E1基因RsaI/PstI多态性与口腔癌易感性的关系：一项荟萃分析。
CYP2E1 RsaI/PstI polymorphisms contributed to oral cancer susceptibility: a meta-analysis.
作者信息
Guo Yang, Zhou Shan, Liu Feng, Zhang Bin
机构信息
Department of Endodontics, The 2nd Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
Department of Orthodontics, The 2nd Affiliated Hospital of Harbin Medical University Harbin, Heilongjiang, China.
出版信息
Int J Clin Exp Pathol. 2015 Nov 1;8(11):14685-92. eCollection 2015.
Several studies have investigated the associations between CYP2E1 RsaI/PstI polymorphisms and oral cancer risk, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. PubMed and China National Knowledge Infrastructure (CNKI) searches were carried out for relevant studies published before September 2014. Meta-analysis was performed with the Stata, version 11.0. A total of 14 case control studies, including 1,962 cases and 3,271 controls, were selected. Overall, significant association was found between the CYP2E1 RsaI/PstI polymorphisms and oral cancer risk (for c1c1 vs. c1c2, OR=0.72, 95% CI=0.56-0.91; for c1c1 vs. c2c2, OR=0.45, 95% CI=0.25-0.82), while not for the dominant model (c1c1 vs. c1c2+c2c2, OR=0.84, 95% CI=0.69-1.01). In the subgroup analysis by ethnicity, statistically significant association was found in Caucasian, East Asian and South Asian. This meta-analysis suggests that the CYP2E1 RsaI/PstI polymorphisms are a risk factor for developing oral cancer.
多项研究调查了CYP2E1 RsaI/PstI基因多态性与口腔癌风险之间的关联，但结果尚无定论。为了更精确地评估两者关系，进行了一项荟萃分析。通过检索PubMed和中国知网（CNKI）获取2014年9月之前发表的相关研究。使用Stata 11.0软件进行荟萃分析。共纳入14项病例对照研究，包括1962例病例和3271例对照。总体而言，发现CYP2E1 RsaI/PstI基因多态性与口腔癌风险之间存在显著关联（c1c1与c1c2相比，OR=0.72，95%CI=0.56-0.91；c1c1与c2c2相比，OR=0.45，95%CI=0.25-0.82），而显性模型（c1c1与c1c2+c2c2相比，OR=0.84，95%CI=0.69-1.01）则无显著关联。在按种族进行的亚组分析中，在白种人、东亚人和南亚人中发现了具有统计学意义的关联。这项荟萃分析表明，CYP2E1 RsaI/PstI基因多态性是口腔癌发生的一个风险因素。
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