Iacopino Saverio, Gasparini Maurizio, Zanon Francesco, Dicandia Cosimo, Distefano Giuseppe, Curnis Antonio, Donati Roberto, Neja Carlo P, Calvi Valeria, Davinelli Mario, Novelli Vanessa, Muto Carmine
Sant'Anna Hospital, Catanzaro, Italy.
Congest Heart Fail. 2010 May-Jun;16(3):104-10. doi: 10.1111/j.1751-7133.2010.00141.x.
Cardiac resynchronization therapy (CRT) is an effective methodology indicated in selected heart failure patients. Identifying responders to the therapy is still challenging. Most studies report that at least 30% of the patients are nonresponders. Baseline characteristics of the Low-Dose Dobutamine Stress Echocardiography to Predict Cardiac Resynchronization Therapy Response (LODO-CRT) trial population are presented. The study investigates dobutamine stress echocardiography's role in predicting CRT response. Two hundred seventy-one CRT candidates were studied. Mean age was 67+/-10 years, 69% were male, 96% had New York Heart Association class III disease, and 39% had heart failure of ischemic etiology. Mean QRS and left ventricular ejection fraction were 146+/-24 ms and 26%+/-6%, respectively. Seventy-seven percent of participants showed contractile reserve. Left ventricular end-diastolic volume was shown to be independently associated with contractile reserve presence. In particular, more dilated ventricles are associated with a lower chance of having contractile reserve. The LODO-CRT trial enrolled a cohort of patients fulfilling criteria for CRT. Dobutamine stress echocardiography was highly feasible and safe in this population. Contractile reserve was associated with healthier ventricles.
心脏再同步治疗（CRT）是一种适用于特定心力衰竭患者的有效方法。识别该治疗的反应者仍然具有挑战性。大多数研究报告称，至少30%的患者无反应。本文介绍了低剂量多巴酚丁胺负荷超声心动图预测心脏再同步治疗反应（LODO-CRT）试验人群的基线特征。该研究调查了多巴酚丁胺负荷超声心动图在预测CRT反应中的作用。对271名CRT候选患者进行了研究。平均年龄为67±10岁，69%为男性，96%患有纽约心脏协会III级疾病，39%患有缺血性病因的心力衰竭。平均QRS波时限和左心室射血分数分别为146±24毫秒和26%±6%。77%的参与者表现出收缩储备。左心室舒张末期容积被证明与收缩储备的存在独立相关。特别是，心室越扩张，具有收缩储备的可能性越低。LODO-CRT试验纳入了一组符合CRT标准的患者。多巴酚丁胺负荷超声心动图在该人群中高度可行且安全。收缩储备与更健康的心室相关。
