Department of Psychology, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada T2N 1N4.
Brain Res. 2010 Aug 12;1348:149-55. doi: 10.1016/j.brainres.2010.06.011. Epub 2010 Jun 15.
Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool in understanding the underlying mechanisms and cause of disease. The triple-transgenic mouse model of AD (3xTg-AD) is the only model to exhibit both Abeta and tau pathology that is characteristic of the human form. The present study characterized the performance of 3xTg-AD mice on several tasks measuring behavioral and cognitive ability. Aged 3xTg-AD females exhibited a higher level of fear and anxiety demonstrated by increased restlessness, startle responses, and freezing behaviors. No differences were observed in muscle strength and visuo-motor coordination. Understanding the behavioral manifestations that occur in this model of AD may aid in the early diagnosis and appropriate treatment of AD symptomology.
阿尔茨海默病（AD）的特征是明显的行为和认知缺陷，与正常衰老所观察到的不同。AD 的转基因模型是理解疾病潜在机制和病因的有前途的工具。AD 的三转基因小鼠模型（3xTg-AD）是唯一表现出与人类形式特征相符的 Abeta 和 tau 病理学的模型。本研究描述了 3xTg-AD 小鼠在几项行为和认知能力测量任务上的表现。年龄较大的 3xTg-AD 雌性小鼠表现出更高水平的恐惧和焦虑，表现为不安、惊跳反应和冻结行为增加。肌肉力量和视觉运动协调方面没有差异。了解这种 AD 模型中发生的行为表现可能有助于 AD 症状的早期诊断和适当治疗。
