Neurobehavioral Phenotyping Platform, Department of Molecular Medicine, Laval University and Laboratory of Endocrinology and Genomics, CHUQ Research Center, 2705 Blvd Laurier, Quebec, QC G1V 4G2, Canada.
Behav Brain Res. 2012 Oct 1;234(2):334-42. doi: 10.1016/j.bbr.2012.07.004. Epub 2012 Jul 14.
3xTg-AD mutant mice are characterized by parenchymal Aβ plaques and neurofibrillary tangles resembling those found in patients with Alzheimer's disease. The mutants were compared with non-transgenic controls in sensorimotor and learning tests. 3xTg-AD mutants were deficient in T-maze reversal, object recognition, and passive avoidance learning. In addition, the mutants showed hypoactivity in two open-field tests, fewer fecal boli in an observation jar, and reduced enclosed arm entries and head-dipping in the elevated plus-maze. On the contrary, the mutants did not differ from controls in pain thresholds, nest-building, and various reflexes determined by the SHIRPA primary screen and were even better on the rotorod test of motor coordination.
3xTg-AD 突变小鼠的特点是实质 Aβ 斑块和神经原纤维缠结，类似于阿尔茨海默病患者的斑块和缠结。将突变体与非转基因对照进行了感觉运动和学习测试。3xTg-AD 突变体在 T 迷宫逆转、物体识别和被动回避学习方面存在缺陷。此外，突变体在两个开阔场测试中表现出活动减少，在观察罐中的粪便更少，在高架十字迷宫中进入封闭臂和头部下降的次数减少。相反，突变体与对照组在疼痛阈值、筑巢和通过 SHIRPA 初步筛选确定的各种反射方面没有差异，在运动协调的转棒测试中甚至表现更好。
