Mador M J, Acevedo F A
Division of Pulmonary Medicine, State University of New York, Buffalo.
J Appl Physiol (1985). 1991 Apr;70(4):1627-32. doi: 10.1152/jappl.1991.70.4.1627.
The purpose of this study was to determine whether induction of either inspiratory muscle fatigue (expt 1) or diaphragmatic fatigue (expt 2) would alter the breathing pattern response to large inspiratory resistive loads. In particular, we wondered whether induction of fatigue would result in rapid shallow breathing during inspiratory resistive loading. The breathing pattern during inspiratory resistive loading was measured for 5 min in the absence of fatigue (control) and immediately after induction of either inspiratory muscle fatigue or diaphragmatic fatigue. Data were separately analyzed for the 1st and 5th min of resistive loading to distinguish between immediate and sustained effects. Fatigue was achieved by having the subjects breathe against an inspiratory threshold load while generating a predetermined fraction of either the maximal mouth pressure or maximal transdiaphragmatic pressure until they could no longer reach the target pressure. Compared with control, there were no significant alterations in breathing pattern after induction of fatigue during either the 1st or 5th min of resistive loading, regardless of whether fatigue was induced in the majority of the inspiratory muscles or just in the diaphragm. We conclude that the development of inspiratory muscle fatigue does not alter the breathing pattern response to large inspiratory resistive loads.
本研究的目的是确定诱发吸气肌疲劳（实验1）或膈肌疲劳（实验2）是否会改变对大吸气阻力负荷的呼吸模式反应。具体而言，我们想知道诱发疲劳是否会导致在吸气阻力负荷期间出现快速浅呼吸。在无疲劳（对照）状态下以及在诱发吸气肌疲劳或膈肌疲劳后立即测量吸气阻力负荷期间的呼吸模式，持续5分钟。对阻力负荷第1分钟和第5分钟的数据分别进行分析，以区分即时效应和持续效应。通过让受试者在产生最大口腔压力或最大跨膈压的预定比例的同时，对着吸气阈值负荷呼吸，直至他们无法再达到目标压力来诱发疲劳。与对照相比，无论疲劳是在大多数吸气肌中诱发还是仅在膈肌中诱发，在阻力负荷的第1分钟或第5分钟诱发疲劳后，呼吸模式均无显著改变。我们得出结论，吸气肌疲劳的发生不会改变对大吸气阻力负荷的呼吸模式反应。
