吸气肌疲劳对呼吸模式及对二氧化碳通气反应的影响。
The effect of inspiratory muscle fatigue on breathing pattern and ventilatory response to CO2.
作者信息
Mador M J, Tobin M J
机构信息
Division of Pulmonary Medicine, State University of New York, Buffalo.
出版信息
J Physiol. 1992 Sep;455:17-32. doi: 10.1113/jphysiol.1992.sp019288.
Abstract
- The effects of inducing inspiratory muscle fatigue on the subsequent breathing pattern were examined during resting unstimulated breathing and during CO2 rebreathing. In addition, we examined whether induction of inspiratory muscle fatigue alters CO2 responsiveness. 2. Global inspiratory muscle fatigue and diaphragmatic fatigue were achieved by having subjects breathe against an inspiratory resistive load while generating a predetermined fraction of either their maximal mouth pressure or maximal transdiaphragmatic pressure until they were unable to generate the target pressure. 3. Induction of inspiratory muscle fatigue had no effect on the subsequent breathing pattern during either unstimulated breathing or during CO2 rebreathing. 4. Following induction of inspiratory muscle fatigue, the slope of the ventilatory response to CO2 was significantly decreased from 18.8 +/- 3.3 during control to 13.8 +/- 2.1 l min-1 (% end-tidal CO2 concentration)-1 with fatigue (P < 0.02).
摘要
- 在静息非刺激呼吸期间以及二氧化碳再呼吸期间，研究了诱发吸气肌疲劳对随后呼吸模式的影响。此外，我们还研究了吸气肌疲劳的诱发是否会改变二氧化碳反应性。2. 通过让受试者在产生其最大口腔压力或最大跨膈压的预定比例的同时，对着吸气阻力负荷呼吸，直至他们无法产生目标压力，从而实现整体吸气肌疲劳和膈肌疲劳。3. 在非刺激呼吸或二氧化碳再呼吸期间，吸气肌疲劳的诱发对随后的呼吸模式均无影响。4. 诱发吸气肌疲劳后，对二氧化碳的通气反应斜率从对照期间的18.8±3.3显著降低至疲劳时的13.8±2.1升·分钟⁻¹（终末潮气二氧化碳浓度%）⁻¹（P<0.02）。
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