Pels A E, Terpstra A H, White T P
Division of Nutrition and Metabolism, Miriam Hospital, Brown University Program-In-Medicine, Providence, Rhode Island 02906.
J Appl Physiol (1985). 1991 Apr;70(4):1743-7. doi: 10.1152/jappl.1991.70.4.1743.
We studied the effects of endurance training on the metabolism of high-density lipoprotein (HDL, 1.063 less than density less than 1.15 kg/l) cholesteryl ester and proteins in rats fed a cholesterol-rich (1%) semipurified diet. The HDL were labeled with 131I in the apoproteins and with cholesteryl-[1-14C]oleate in the esters. The HDL were intravenously administered to endurance-trained (n = 10) and cage-sedentary (n = 10) rats. Blood samples were taken over the next 36 h while the rats were conscious and feeding. The trained rats had higher plasma HDL cholesterol (0.72 vs. 0.28 mM) and HDL apoprotein (461 vs. 267 mg/l) concentrations than the sedentary rats. The production or disposal rate of HDL cholesteryl ester was higher in the trained rats (1.36 mumol/h) than in the sedentary rats (0.72 mumol/h), whereas the production or disposal rate of HDL apoproteins was similar in the trained (0.64 mg/h) and sedentary (0.60 mg/h) rats. The residence time of the HDL cholesteryl esters (4.72 +/- 0.22 vs. 3.37 +/- 0.21 h) and HDL apoprotein (7.65 +/- 0.36 vs. 4.55 +/- 0.28 h) was longer for the trained than for the sedentary rats. These data indicate that endurance training resulted in a significant change in the metabolism of HDL cholesteryl esters and apoproteins as well as an increase in their concentrations.
我们研究了耐力训练对喂食富含胆固醇（1%）半纯化饮食的大鼠高密度脂蛋白（HDL，密度1.063至1.15 kg/l）胆固醇酯和蛋白质代谢的影响。HDL的载脂蛋白用131I标记，酯类用胆固醇-[1-14C]油酸酯标记。将HDL静脉注射给耐力训练组（n = 10）和笼养久坐组（n = 10）大鼠。在接下来的36小时内，在大鼠清醒并进食时采集血样。训练组大鼠的血浆HDL胆固醇（0.72对0.28 mM）和HDL载脂蛋白（461对267 mg/l）浓度高于久坐组大鼠。训练组大鼠HDL胆固醇酯的生成或清除率（1.36 μmol/h）高于久坐组大鼠（0.72 μmol/h），而训练组（0.64 mg/h）和久坐组（0.60 mg/h）大鼠HDL载脂蛋白的生成或清除率相似。训练组大鼠HDL胆固醇酯（4.72 +/- 0.22对3.37 +/- 0.21 h）和HDL载脂蛋白（7.65 +/- 0.36对4.55 +/- 0.28 h）的驻留时间比久坐组大鼠长。这些数据表明，耐力训练导致HDL胆固醇酯和载脂蛋白的代谢发生显著变化，以及它们的浓度增加。
