Vanderbilt University School of Medicine, Department of Pathology, 1161 21 Ave. South. C2217A MCN, Nashville, TN 37232, USA.
Am J Pathol. 2010 Jul;177(1):4-9. doi: 10.2353/ajpath.2010.090615. Epub 2010 Jun 17.
Atherosclerosis, a chronic vascular disease, is the underlying cause of over half the deaths in the United States each year. Variations in local vascular hemodynamics predispose select sites in the vasculature to atherosclerosis, and the atherosclerotic lesions, in turn alter the biomechanical functioning of the local microenvironment, the consequences of which are not well understood on a molecular level. Further progress in the field of atherosclerosis will require an understanding of the relationship between biomechanics, the tissue microenvironment, and the cellular and molecular response to these factors. This review summarizes this field, particularly within the context of the vascular smooth muscle cell.
动脉粥样硬化是一种慢性血管疾病，是导致美国每年半数以上死亡的根本原因。局部血管血液动力学的变化使血管的特定部位易发生动脉粥样硬化，而动脉粥样硬化病变又反过来改变局部微观环境的生物力学功能，但其在分子水平上的后果尚不清楚。在动脉粥样硬化领域取得进一步进展，需要了解生物力学、组织微环境以及细胞和分子对这些因素的反应之间的关系。本综述总结了这一领域，特别是在血管平滑肌细胞的背景下。
