Heart Research Institute, Sydney, NSW, Australia (A.M., A.L., S.P.).
Faculty of Medicine and Health (A.M., R.R.), The University of Sydney, NSW, Australia.
Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):e74-e84. doi: 10.1161/ATVBAHA.121.316093. Epub 2022 Feb 3.
Clonal expansion is a process that can drive pathogenesis in human diseases, with atherosclerosis being a prominent example. Despite advances in understanding the etiology of atherosclerosis, clonality studies of vascular cells remain in an early stage. Recently, several paradigm-shifting preclinical studies have identified clonal expansion of progenitor cells in the vasculature in response to atherosclerosis. This review provides an overview of cell clonality in atherosclerotic progression, focusing particularly on smooth muscle cells and macrophages. We discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology. The further probing of these mechanisms will provide innovative directions for future progress in the understanding and therapy of atherosclerosis and its associated cardiovascular diseases.
克隆扩增是一个可以驱动人类疾病发病机制的过程，动脉粥样硬化就是一个突出的例子。尽管人们对动脉粥样硬化的病因学有了更多的了解，但血管细胞的克隆性研究仍处于早期阶段。最近，一些具有开创性的临床前研究已经确定了血管中祖细胞对动脉粥样硬化的克隆扩增。本综述概述了动脉粥样硬化进展中的细胞克隆性，特别关注平滑肌细胞和巨噬细胞。我们讨论了最新研究中的关键发现，这些发现深入了解了血管细胞克隆扩增对疾病病理学的作用机制。进一步探究这些机制将为理解和治疗动脉粥样硬化及其相关心血管疾病的未来进展提供创新性方向。
