热带海洋海绵的水提物和有机溶剂提取物的生物活性。
Biological activities of aqueous and organic extracts from tropical marine sponges.
机构信息
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia.
出版信息
Mar Drugs. 2010 Apr 28;8(5):1550-66. doi: 10.3390/md8051550.
We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous and organic solvents and were tested for hemolytic, hemagglutinating, antibacterial and anti-acetylcholinesterase (AChE) activities, as well as their ability to inhibit or activate cell protein phosphatase 1 (PP1). The most interesting activities were obtained from extracts of Ircinia felix, Pandaros acanthifolium, Topsentia ophiraphidites, Verongula rigida and Neofibularia nolitangere. Aqueous and organic extracts of I. felix and V. rigida showed strong antibacterial activity. Topsentia aqueous and some organic extracts were strongly hemolytic, as were all organic extracts from I. felix. The strongest hemolytic activity was observed in aqueous extracts from P. acanthifolium. Organic extracts of N. nolitangere and I. felix inhibited PP1. The aqueous extract from Myrmekioderma styx possessed the strongest hemagglutinating activity, whilst AChE inhibiting activity was found only in a few sponges and was generally weak, except in the methanolic extract of T. ophiraphidites.
我们报告了对来自加勒比海（库拉索岛）的 35 种海绵物种和来自大堡礁（蜥蜴岛）的 8 种海绵物种的 66 种提取物进行的筛选测试。提取物以水相和有机溶剂制备，并测试了溶血、血凝、抗菌和抗乙酰胆碱酯酶（AChE）活性，以及它们抑制或激活细胞蛋白磷酸酶 1（PP1）的能力。最有趣的活性来自 Ircinia felix、Pandaros acanthifolium、Topsentia ophiraphidites、Verongula rigida 和 Neofibularia nolitangere 的提取物。I. felix 和 V. rigida 的水相和有机溶剂提取物表现出强烈的抗菌活性。Topsentia 的水相和一些有机溶剂提取物具有很强的溶血活性，而来自 I. felix 的所有有机溶剂提取物也是如此。在 P. acanthifolium 的水提取物中观察到最强的溶血活性。N. nolitangere 和 I. felix 的有机溶剂提取物抑制了 PP1。来自 Myrmekioderma styx 的水提取物具有最强的血凝活性，而只有少数几种海绵具有 AChE 抑制活性，且通常较弱，除了 T. ophiraphidites 的甲醇提取物之外。
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