Sarita Rajender P, Ramasree D, Bhargavi K, Vasavi M, Uma V
Department of Chemistry, Nizam College, Basheerbagh, Hyderabad, Andhra Pradesh, India.
J Recept Signal Transduct Res. 2010 Aug;30(4):206-13. doi: 10.3109/10799893.2010.488649.
Cancer prevention is a global priority, but history indicates that the journey towards achieving the goal is difficult. Various cyclin dependent kinase complexes (CDKs/cyclins) operate as major cell signaling components in all stages of cell cycle. CDK/cyclin protein complexes, regulating the cell cycle, are conserved during evolution. In cancer cells, cell division is uncontrolled and CDKs/cyclins become 'check-points' or targets. Keeping this in view the proteins cyclin C, cyclin D2, CDKN1C, and Growth Arrest and DNA Damage (GADD45alpha) which play a major role in regulating CDK/cyclin complexes and operate in the initial stages of cell cycle (G(0) phase-S phase), have been identified as promising targets. Targeting critical regulators of cell-cycle signaling components by applying modern computational techniques is projected to be a potential tool for future cancer research.
癌症预防是全球优先事项，但历史表明实现这一目标的道路充满困难。各种细胞周期蛋白依赖性激酶复合物（CDK/细胞周期蛋白）在细胞周期的所有阶段作为主要的细胞信号成分发挥作用。调节细胞周期的CDK/细胞周期蛋白复合物在进化过程中是保守的。在癌细胞中，细胞分裂不受控制，CDK/细胞周期蛋白成为“检查点”或靶点。鉴于此，细胞周期蛋白C、细胞周期蛋白D2、CDKN1C以及生长停滞和DNA损伤（GADD45α）蛋白在调节CDK/细胞周期蛋白复合物中起主要作用，并在细胞周期的初始阶段（G0期-S期）发挥作用，已被确定为有前景的靶点。应用现代计算技术靶向细胞周期信号成分的关键调节因子预计将成为未来癌症研究的潜在工具。
