Department of Behavioral Science, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536-0086, USA.
Am J Drug Alcohol Abuse. 2010 Jul;36(4):220-7. doi: 10.3109/00952990.2010.494213.
Several studies suggest a link between stimulant abuse and attention-deficit hyperactivity disorder (ADHD) symptoms (e.g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine.
Participants were classified into a High- (n = 8) or Low-Score (n = 9) group based on their responses on a rating scale that assessed inattention and hyperactivity symptoms.
The participants did not differ across the High-Score and Low-Score groups in their ability to discriminate d-amphetamine. The participants in the High-Score group were significantly more sensitive to the positive participant-rated effects of d-amphetamine (e.g., Good Effects, Like Drug), but less sensitive to drug-induced increases in blood pressure and heart rate.
The selective increase in positive subjective effects of d-amphetamine suggests that individuals with subclinical inattention and hyperactivity symptoms may have increased vulnerability to stimulant abuse.
多项研究表明，兴奋剂滥用与注意力缺陷多动障碍（ADHD）症状之间存在关联（例如，注意力不集中和多动）。为了进一步评估这种关系的本质，本研究探讨了亚临床注意力不集中和多动症状与 d-苯丙胺的行为效应之间的关联。
根据评估注意力不集中和多动症状的评分量表上的反应，将参与者分为高分（n = 8）或低分（n = 9）组。
高分组和低分组在区分 d-苯丙胺的能力方面没有差异。高分组的参与者对 d-苯丙胺的积极自评效应（例如，良好效应，喜欢药物）更为敏感，但对血压和心率升高的药物诱导反应则不太敏感。
d-苯丙胺的积极主观效应选择性增加表明，亚临床注意力不集中和多动症状的个体可能对兴奋剂滥用的易感性增加。
