TSLP 多态性与哮喘的发生具有性别特异性。
TSLP polymorphisms are associated with asthma in a sex-specific fashion.
机构信息
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Allergy. 2010 Dec;65(12):1566-75. doi: 10.1111/j.1398-9995.2010.02415.x.
BACKGROUND
Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion.
METHODS
We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS).
MAIN RESULTS
Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 × 10(-6) ). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 × 10(-4) ). Findings for rs2289276 were consistent in all cohorts except the FHS.
CONCLUSIONS
TSLP variants are associated with asthma in a sex-specific fashion.
背景
胸腺基质淋巴细胞生成素（TSLP）中的单核苷酸多态性（SNPs）与 IgE（在女孩中）和哮喘（总体而言）有关。我们试图确定 TSLP SNPs 是否以性别特异性的方式与哮喘相关。
方法
我们在哥斯达黎加患有哮喘的儿童的家庭中，对 TSLP 中的 SNPs 与哮喘之间的关联进行了常规和性别分层分析。在儿童哮喘管理计划中的白人和非裔美国人参与者、非裔美国人的非洲裔侨民哮喘基因组研究中、白人和西班牙裔在美国儿童健康研究中的参与者以及在弗雷明汉心脏研究中的白种人中，都发现了显著的发现。
主要结果
在所有队列的综合分析中，TSLP 中的两个 SNPs（rs1837253 和 rs2289276）与哮喘风险降低显著相关（分别为 2×10(-5) 和 1×10(-5) 的 P 值）。在性别分层分析中，rs1837253 的 T 等位基因仅与男性哮喘风险降低显著相关（P = 3×10(-6)）。相反，rs2289276 的 T 等位基因仅与女性哮喘风险降低显著相关（P = 2×10(-4)）。除了弗雷明汉心脏研究外，rs2289276 的发现与所有队列一致。
结论
TSLP 变体以性别特异性的方式与哮喘相关。
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