Phanthumchinda K, Srikiatkachorn A
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1991 Feb;74(2):71-9.
Forty cases with several forms of spinocerebellar degenerations were studied. The diagnosis was based on an appropriate clinical picture, radiological investigation and family history. There are multiple variants of spinocerebellar degeneration and classification of these diseases remains unsatisfactory and therefore controversial. We classified cases into three main groups. The numbers of cases in each of these groups were as follows: cerebellar group = 16 cases, cerebellar plus group = 9 cases, spinal group = 15 cases. The age, age of onset, mode of inheritance, clinical pictures and cerebrospinal fluid analysis of these cases were discussed. Results of various radiological investigations of these cases were reviewed. From our observations we can conclude that the morphologic changes seen in radiological investigations in our cases were more varied than the observed clinical syndromes. The cause of these syndromes remains unknown and there is no established treatment for spinocerebellar degeneration. We can only offer symptomatic treatment, physiotherapy and genetic counselling for this group of patients.
对40例患有多种形式脊髓小脑变性的患者进行了研究。诊断基于适当的临床表现、放射学检查和家族史。脊髓小脑变性有多种变体，这些疾病的分类仍不尽人意，因此存在争议。我们将病例分为三个主要组。每组病例数如下：小脑组 = 16例，小脑加组 = 9例，脊髓组 = 15例。讨论了这些病例的年龄、发病年龄、遗传方式、临床表现和脑脊液分析。回顾了这些病例各种放射学检查的结果。从我们的观察中可以得出结论，我们病例放射学检查中所见的形态学变化比观察到的临床综合征更多样化。这些综合征的病因仍然未知，且脊髓小脑变性尚无既定的治疗方法。对于这组患者，我们只能提供对症治疗、物理治疗和遗传咨询。
