单纯疱疹病毒感染与神经源性细胞：非允许性相互作用的特征

Infection by herpes simplex virus and cells of nervous system origin: characterization of a non-permissive interaction.

作者信息

Adler R, Glorioso J C, Levine M

出版信息

J Gen Virol. 1978 Apr;39(1):9-20. doi: 10.1099/0022-1317-39-1-9.

PMID:205630

Abstract

Replication of herpes simplex virus type I (HSV-I) was studied in various cell lines of rat nervous system origin. Infection of neonatal rat glial primary cells with HSV-I, strain KOS, produced normal yields of progeny virus. Glioma lines B9 and B15 were permissive, the neuronal line B50 was partially restricted (10 to 100-fold reduction) and the neuronal line B103 was non-permissive (greater than 1000-fold reduction) for HSV-I (KOS) replication. Synthesis of virus DNA in infected B103 cells was not detected. However, at least some virus macromolecular synthesis was induced, including production of thymidine kinase, DNA polymerase and virus structural proteins.

摘要

对单纯疱疹病毒I型（HSV-I）在源自大鼠神经系统的各种细胞系中的复制情况进行了研究。用HSV-I KOS株感染新生大鼠神经胶质原代细胞，产生了正常产量的子代病毒。胶质瘤细胞系B9和B15是允许性的，神经元细胞系B50对HSV-I（KOS）复制有部分限制（产量降低10至100倍），而神经元细胞系B103是非允许性的（产量降低超过1000倍）。在受感染的B103细胞中未检测到病毒DNA的合成。然而，至少诱导了一些病毒大分子的合成，包括胸苷激酶、DNA聚合酶和病毒结构蛋白的产生。