Garrity P, Szelc C, Paquette C, McEvoy M, Millette R, Adler R
Antimicrob Agents Chemother. 1982 Mar;21(3):450-5. doi: 10.1128/AAC.21.3.450.
Incubation of herpes simplex virus type 1-infected cells with succinyl-concanavalin A, a derivative of the jack bean lectin concanavalin A, resulted in the decreased production of virus. The mode of inhibition by the lectin was unclear. No effect was apparent on the level of viral DNA synthesis. However, incubation of infected cells with increasing concentrations of the lectin appeared to result in a decrease in the quantity of viral protein produced within the cell. A reduction in the virus titer of 57 to 64% was observed upon direct incubation of extracellular virus in the presence of 50 to 100 micrograms of succinyl-concanavalin A per ml.
用刀豆球蛋白A的衍生物琥珀酰刀豆球蛋白A处理单纯疱疹病毒1型感染的细胞，会导致病毒产量下降。凝集素的抑制方式尚不清楚。对病毒DNA合成水平没有明显影响。然而，用浓度不断增加的凝集素处理感染细胞，似乎会导致细胞内产生的病毒蛋白数量减少。当每毫升含有50至100微克琥珀酰刀豆球蛋白A时，直接处理细胞外病毒，可观察到病毒滴度降低了57%至64%。
