氨基酸合成的新方法：在复杂天然产物中的应用
New Tricks in Amino Acid Synthesis: Applications to Complex Natural Products.
作者信息
Williams Robert M, Burnett Cameron M
机构信息
Department of Chemistry, Colorado State University, Ft. Collins, CO 80523.
出版信息
ACS Symp Ser Am Chem Soc. 2009 Jun 14;1009:420-442.
Abstract
We report the application of diphenyloxazinone glycinate chiral templates to asymmetric syntheses of cylindrospermospin, 7-epi-cylindrospermopsin, 7-deoxycylindrospermopsin, and spirotryprostatins A and B. Synthetic studies toward quinine, nakadomarin A, and palau'amine using these templates are also described.
摘要
我们报道了二苯基恶唑啉酮甘氨酸酯手性模板在柱孢藻毒素、7-表柱孢藻毒素、7-脱氧柱孢藻毒素以及螺旋曲菌素A和B的不对称合成中的应用。还描述了使用这些模板对奎宁、中田马林A和帕劳胺的合成研究。
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本文引用的文献
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Angew Chem Int Ed Engl. 2007;46(35):6586-94. doi: 10.1002/anie.200701798.
2
Total synthesis of spirotryprostatin B via diastereoselective prenylation.通过非对映选择性异戊烯基化全合成螺旋曲菌素B
Org Lett. 2007 Jul 19;9(15):2763-6. doi: 10.1021/ol070971k. Epub 2007 Jun 26.
3
Synthetic studies on quinine: quinuclidine construction via a ketone enolate regio- and diastereoselective Pd-mediated allylic alkylation.奎宁的合成研究：通过酮烯醇盐区域和非对映选择性钯介导的烯丙基烷基化构建奎宁环。
Org Lett. 2006 Aug 31;8(18):4051-4. doi: 10.1021/ol061524s.
4
Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis.7-脱氧柱孢藻毒素假定结构的合成：抑制蛋白质合成并不需要C7位的氧合作用。
Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3879-81. doi: 10.1002/anie.200500520.
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Total synthesis of (-)-7-epicylindrospermopsin, a toxic metabolite of the freshwater cyanobacterium aphanizomenonovalisporum, and assignment of its absolute configuration.淡水蓝藻阿氏浮丝藻的有毒代谢产物（-）-7-表柱孢藻毒素的全合成及其绝对构型的确定。
J Org Chem. 2005 Mar 18;70(6):1963-77. doi: 10.1021/jo0486387.
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Org Lett. 2004 Nov 25;6(24):4539-41. doi: 10.1021/ol048126e.
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A concise asymmetric synthesis of the marine hepatotoxin 7-epicylindrospermopsin.
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Catalytic asymmetric total syntheses of quinine and quinidine.奎宁和奎尼丁的催化不对称全合成。
J Am Chem Soc. 2004 Jan 28;126(3):706-7. doi: 10.1021/ja039550y.
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