钯催化的 2-硝基苯甲酸的脱羧 Heck 乙烯基化反应在 CuF₂存在下进行。

Pd-catalyzed decarboxylative Heck vinylation of 2-nitrobenzoates in the presence of CuF₂.

机构信息

Department of Chemistry, Organic Chemistry, Technische Universität Kaiserslautern, Erwin-Schrödinger-Strasse, Geb. 54, D-67663 Kaiserslautern, Germany.

出版信息

Beilstein J Org Chem. 2010 May 3;6:43. doi: 10.3762/bjoc.6.43.

DOI:10.3762/bjoc.6.43

PMID:20563276

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2887305/

Abstract

A new protocol for the decarboxylative Heck vinylation of benzoic acids is disclosed. In the presence of a catalyst system generated in situ from Pd(OAc)₂ (2 mol %), CuF₂ (2 equiv), and benzoquinone (0.5 equiv) in NMP, a wide range of olefins were coupled with various 2-nitrobenzoates at 130 ° C with the release of carbon dioxide to afford the corresponding vinyl arenes in good yields.

摘要

本发明公开了一种用于苯甲酸脱羧 Heck 乙烯基化的新方法。在 Pd(OAc)₂（2mol%）、CuF₂（2 当量）和邻苯醌（0.5 当量）原位生成的催化剂体系存在下，在 NMP 中于 130°C 下，各种烯烃与各种 2-硝基苯甲酸酯反应，释放出二氧化碳，以良好的收率得到相应的芳基乙烯。