无盐生成的Heck反应：芳族羧酸酐作为芳基化试剂
Heck Reactions without Salt Formation: Aromatic Carboxylic Anhydrides as Arylating Agents.
作者信息
Stephan Massoud S, Teunissen Antonius J J M, Verzijl Gerard K M, de Vries Johannes G
机构信息
DSM Research, Dept. Fine Chemicals, PO Box 18, NL-6160 MD Geleen (The Netherlands), Fax: (+31) 46-476-7604.
出版信息
Angew Chem Int Ed Engl. 1998 Mar 16;37(5):662-664. doi: 10.1002/(SICI)1521-3773(19980316)37:5<662::AID-ANIE662>3.0.CO;2-0.
Environmentally benign and economical production of arylated olefins can be achieved by a new variant of the Heck reaction in which no halogen salts are formed. The trick is the use of aromatic carboxylic anhydrides 1 as arylating agents. With halide-activated palladium chloride as catalyst, which requires no phosphane ligands, the olefins 2 can be prepared according to Equation (a) in good yields.
通过Heck反应的一种新变体可以实现环境友好且经济的芳基化烯烃生产，该变体不会形成卤盐。关键在于使用芳族羧酸酐1作为芳基化试剂。以卤化物活化的氯化钯为催化剂（无需膦配体），可以根据方程式（a）以高收率制备烯烃2。
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