Chen Lijun, Ju Lin, Bustin Katelyn A, Hoover Jessica M
C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia, USA.
Chem Commun (Camb). 2015 Oct 18;51(81):15059-62. doi: 10.1039/c5cc06645j.
A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.
开发了一种铜催化的苯并恶唑与2-硝基苯甲酸的氧化脱羧偶联反应。该方法有利于富电子的苯并恶唑和缺电子的苯甲酸，并能以良好的产率制备多种芳基化苯并恶唑。产物产率的趋势表明脱羧和C-H芳基化步骤之间存在微妙的平衡。
