Fowler C L, Brooks S P, Squire R, Rich G A, Rossman J E, Finegold M J, Allen J E, Cooney D R
Department of Surgery, School of Medicine and Biomedical Sciences, State University of New York, Buffalo.
J Pediatr Surg. 1991 Apr;26(4):381-7; discussion 387-8. doi: 10.1016/0022-3468(91)90983-z.
Advanced neuroblastoma treated with standard chemotherapy has a poor prognosis. Combination immunotherapy for murine neuroblastoma with retinyl palmitate, low-dose cyclophosphamide, and interleukin-2 resulted in increased survival, impaired tumor growth, easier surgical resection, and increased class I expression or tumor cells. Preoperative immunotherapy may be useful in treatment of advanced human neuroblastoma.
采用标准化疗治疗的晚期神经母细胞瘤预后较差。用视黄醇棕榈酸酯、低剂量环磷酰胺和白细胞介素-2联合免疫疗法治疗鼠神经母细胞瘤，可提高生存率、抑制肿瘤生长、使手术切除更容易，并增加I类分子表达或肿瘤细胞。术前免疫疗法可能对晚期人类神经母细胞瘤的治疗有用。
