Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada.
Prostate. 2010 Nov 1;70(15):1628-35. doi: 10.1002/pros.21198.
Plasma insulin concentration is increased in prostate cancer patients during androgen deprivation therapy (ADT) and hyperinsulinemia has been associated with aggressive prostate cancer behavior. To investigate the possible role of castration-induced hyperinsulinemia as a mechanism that may attenuate the beneficial effects of ADT in patients with prostate cancer, a murine model would be useful. We therefore investigated long-term metabolic effects of castration in several mouse models.
We studied the long-term influence of castration on energy intake, body weight, glucose tolerance, plasma-insulin, plasma insulin-like growth factor-1 (IGF-1), plasma adiponectin, and plasma leptin in C57BL/6, Swiss nu/nu, and CB17 scid mice receiving various diets. In each case, mice were randomized to have either bilateral orchiectomy or a sham operation.
Energy intake, body weight, blood glucose levels in glucose tolerance test, plasma insulin, plasma IGF-1, and plasma leptin level in all had a trend to be decreased in castrated as compared to sham operated mice. Plasma adiponectin level was increased in the castrated mice.
The effects of castration on glucose, insulin, and related markers in several mouse models studied does not coincide with clinical observations; further studies in this area will require clinical research and/or the use of alternate models such as the dog.
在雄激素剥夺治疗（ADT）期间，前列腺癌患者的血浆胰岛素浓度升高，并且高胰岛素血症与侵袭性前列腺癌行为有关。为了研究去势诱导的高胰岛素血症作为一种可能的机制，这种机制可能会减弱 ADT 对前列腺癌患者的有益作用，建立一种鼠模型将是有用的。因此，我们研究了去势对几种小鼠模型的长期代谢影响。
我们研究了去势对能量摄入、体重、葡萄糖耐量、血浆胰岛素、血浆胰岛素样生长因子-1（IGF-1）、血浆脂联素和血浆瘦素的长期影响，这些小鼠接受了各种饮食。在每种情况下，将小鼠随机分为双侧睾丸切除术或假手术。
与假手术组相比，去势组的能量摄入、体重、葡萄糖耐量试验中的血糖水平、血浆胰岛素、血浆 IGF-1 和血浆瘦素水平均呈下降趋势。血浆脂联素水平在去势组中增加。
在几种研究的小鼠模型中，去势对葡萄糖、胰岛素和相关标志物的影响与临床观察不一致；该领域的进一步研究将需要临床研究和/或使用替代模型，如狗。
