脂肪组织中的性别和性差异。
Gender and Sex Differences in Adipose Tissue.
机构信息
Pediatric Endocrinology, University of Michigan Medical School, Medical Professional Building, D1205 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5718, USA.
出版信息
Curr Diab Rep. 2018 Jul 30;18(9):69. doi: 10.1007/s11892-018-1031-3.
Abstract
PURPOSE OF REVIEW
As the ongoing epidemic of adult and childhood obesity grows, it puts a greater burden on individuals and the healthcare system due to increased prevalence of obesity-associated diseases. An important area that has gained much attention recently is the sex and gender difference related to obesity and associated complications. Basic science and clinical studies have now improved our understanding of obesity and have discovered adipose tissue biology to be key in metabolism.
RECENT FINDINGS
There is evidence related to the sex dichotomy in obesity in a variety of areas including adipocyte function, sex hormone effects, genetics, and metabolic inflammation leading to critical differences in adipose tissue biology. The sex and gender difference in adipose tissue is a factor that should be considered when studying an individuals' risk for obesity and metabolic dysfunction. This understanding is important for strategizing treatment and prevention measures.
摘要
目的综述
随着成人和儿童肥胖症的持续流行，由于肥胖相关疾病的患病率增加，个人和医疗保健系统的负担也越来越重。最近一个备受关注的重要领域是与肥胖及其相关并发症相关的性别差异。基础科学和临床研究现已提高了我们对肥胖的认识，并发现脂肪组织生物学在新陈代谢中起着关键作用。
最近的发现
在包括脂肪细胞功能、性激素作用、遗传学和代谢炎症在内的多个领域都有与肥胖性别二态性相关的证据，这导致了脂肪组织生物学的重要差异。在研究个体肥胖和代谢功能障碍的风险时，应考虑脂肪组织中的性别差异。这种认识对于制定治疗和预防措施的策略非常重要。
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