Institute for the Study of Child Development, Robert Wood Johnson Autism Center, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 97 Paterson Street, New Brunswick, NJ 08903, USA.
Dev Psychobiol. 2010 Dec;52(8):755-63. doi: 10.1002/dev.20471.
In this pilot study the severity of autism spectrum disorders (ASD) was associated with alterations in white matter development. Children with ASD and without ASD were assessed by magnetic resonance imaging (MRI) for their myelination development on a regional basis. Measures were obtained in medial frontal cortex, temporal poles, and temporo-parietal junction in both left and right hemispheres. Children with ASD showed myelination that was greater than expected for their age in both left and right medial frontal cortex and showed myelination that was less than expected in left temporo-parietal junction. The severity of ASD symptoms, as assessed by the Autism Diagnostic Observation Schedule-Generic, was associated more with left hemisphere alterations than right hemisphere.
在这项初步研究中，自闭症谱系障碍 (ASD) 的严重程度与白质发育的改变有关。通过磁共振成像 (MRI) 对 ASD 儿童和非 ASD 儿童进行区域性髓鞘发育评估。在左右半球的额内侧皮质、颞极和颞顶联合区测量了各项指标。ASD 儿童的左右额内侧皮质的髓鞘发育均高于其年龄预期，而左颞顶联合区的髓鞘发育则低于预期。自闭症诊断观察量表-通用版 (Autism Diagnostic Observation Schedule-Generic) 评估的 ASD 症状严重程度与左半球的改变比右半球更相关。
