INSERM, Unité 955 and Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Henri Mondor-Albert Chenevier, Pöle de Psychiatrie, Créteil Cedex, France.
J Trauma Stress. 2010 Jun;23(3):376-83. doi: 10.1002/jts.20532.
Childhood trauma has been suggested to be involved in the susceptibility to bipolar disorder. However, case-control studies are lacking, and the preferential implication and the dose-effect of different trauma subtypes remain poorly investigated. Two hundred six bipolar patients and 94 controls completed the Childhood Trauma Questionnaire (CTQ; Bernstein et al., 1994). The CTQ total score was higher for bipolar patients than for controls. The presence of multiple trauma was significantly more frequent in bipolar patients than in controls (63% vs. 33%). Multiple logistic regression suggested that only emotional abuse was associated with bipolar disorder with a suggestive dose-effect. Clinical practice should include systematic assessment of childhood trauma among bipolar patients with a particular focus on emotional abuse.
儿童时期创伤被认为与双相情感障碍的易感性有关。然而，目前缺乏病例对照研究，不同创伤亚型的优先影响和剂量效应仍未得到充分研究。206 名双相情感障碍患者和 94 名对照完成了童年创伤问卷（CTQ；Bernstein 等人，1994 年）。CTQ 总分在双相情感障碍患者中高于对照组。多重创伤的存在在双相情感障碍患者中明显更为频繁（63%比 33%）。多变量逻辑回归表明，只有情感虐待与双相情感障碍有关，且存在提示性的剂量效应。临床实践应包括在双相情感障碍患者中系统评估儿童期创伤，特别关注情感虐待。
