[癸酸与α-环糊精包合对头孢美唑钠栓在家兔直肠吸收的影响]
[Effect of inclusion complexation of decanoic acid with alpha-cyclodextrin on rectal absorption of cefmetazole sodium suppository in rabbits].
作者信息
Yanagi H, Ishikura N, Kenmotsu H, Yagi N, Goto K, Kato S, Sumiya S, Takada M
机构信息
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
出版信息
Yakugaku Zasshi. 1991 Jan;111(1):65-9. doi: 10.1248/yakushi1947.111.1_65.
Inclusion complex of decanoic acid (DA) with alpha-cyclodextrin (alpha-CyD) was prepared as an additive of cefmetazole sodium (CMZ) suppository and rectally administered to rabbits. The resulting complexation was examined by the phase solubility method, differential scanning calorimetry (DSC) and X-ray diffractometry. Plasma concentration and AUC of CMZ after rectal administration of a suppository containing DA/alpha-CyD complex to rabbits increased more significantly than those with none additive.
制备了癸酸（DA）与α-环糊精（α-CyD）的包合物作为头孢美唑钠（CMZ）栓剂的添加剂，并经直肠给药于家兔。通过相溶解度法、差示扫描量热法（DSC）和X射线衍射法对形成的络合物进行了检测。给家兔直肠给药含DA/α-CyD络合物的栓剂后，CMZ的血浆浓度和药时曲线下面积（AUC）比未添加任何添加剂时显著增加。
Zotero 插件