College of Oriental Medicine, Kyungwon University, Seongnam, Republic of Korea.
Phytother Res. 2010 Dec;24(12):1781-7. doi: 10.1002/ptr.3161.
Epimedium brevicornum Maxim (Berberidaceae) possesses estrogenic properties. It is one of the most widespread herbal remedies used in Oriental medicine. The present study investigated the effects of Epimedium brevicornum water extract (EB) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced RAW264.7 macrophages. EB significantly inhibited the production of nitric oxide (NO), interleukin (IL)-3, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, vascular endothelial growth factor, monocyte chemotactic protein-1 and granulocyte macrophage-colony stimulating factor in LPS-induced RAW264.7 cells at concentrations of 25, 50, 100 and 200 μg/mL (p < 0.05). These results suggest that EB has antiinflammatory activity related to its inhibition of NO, cytokine, chemokine and growth factor production in macrophages.
朝藿定具有雌激素样作用。它是东方医学中使用最广泛的草药之一。本研究探讨了朝藿定水提取物 (EB) 对脂多糖 (LPS) 诱导的 RAW264.7 巨噬细胞分泌的促炎介质的影响。EB 能显著抑制 LPS 诱导的 RAW264.7 细胞中一氧化氮 (NO)、白细胞介素 (IL)-3、IL-10、IL-12p40、干扰素诱导蛋白-10、角质形成细胞衍生的趋化因子、血管内皮生长因子、单核细胞趋化蛋白-1 和粒细胞巨噬细胞集落刺激因子的产生，其浓度为 25、50、100 和 200μg/mL(p<0.05)。这些结果表明，EB 具有抗炎活性，与其抑制巨噬细胞中 NO、细胞因子、趋化因子和生长因子的产生有关。
