Abdelaziz Ahmed S, Kamel Mohamed A, Ahmed Amany I, Shalaby Shimaa I, El-Darier Salama M, Magdy Beshbishy Amany, Batiha Gaber El-Saber, Alomar Suliman Y, Khodeer Dina M
Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.
Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt.
Antibiotics (Basel). 2020 Jun 11;9(6):318. doi: 10.3390/antibiotics9060318.
Maxim (EbM) is a well-known Chinese herb that has been widely used for the treatment of several diseases. The main purpose of this study is to examine the role of extract in certain andrological parameters in rats as a natural modulator for adverse viewpoints associated with chronic administration of tramadol (TAM). Fifty rats were categorized into five groups. Untreated rats were known as Group I, whereas rats in Groups II and III were administered 2.43 g/kg/day of extract and 50 mg/kg/day of TAM for 130 consecutive days, respectively. Both of Groups IV and V were administered TAM for 65 successive days, followed by concomitant use of both drugs for another 65 days, with the extract at doses of 0.81 and 2.43 g/kg/day, respectively. TAM showed an injurious effect on sperm attributes, serum hormones, tissue malondialdehyde, superoxide dismutase, and nitric oxide. Elevation of the apoptotic marker Bax and a reduction of Bcl2 were recorded. Histopathological abnormalities have been reported in rat testicles. Rats treated with extract with TAM showed an improvement in all the parameters tested. It could be presumed that extract plus TAM exhibits a promising effect on the enhancement of male anti-infertility effects.
马克西姆（EbM）是一种著名的中草药，已被广泛用于治疗多种疾病。本研究的主要目的是研究提取物对大鼠某些雄性生殖参数的作用，作为与长期服用曲马多（TAM）相关不良观点的天然调节剂。五十只大鼠被分为五组。未治疗的大鼠为第一组，而第二组和第三组的大鼠分别连续130天给予2.43 g/kg/天的提取物和50 mg/kg/天的TAM。第四组和第五组均连续65天给予TAM，随后两种药物联合使用另外65天，提取物剂量分别为0.81和2.43 g/kg/天。TAM对精子属性、血清激素、组织丙二醛、超氧化物歧化酶和一氧化氮有损伤作用。记录到凋亡标志物Bax升高，Bcl2降低。大鼠睾丸出现组织病理学异常。用提取物与TAM治疗的大鼠在所有测试参数上均有改善。可以推测，提取物加TAM对增强男性抗不育作用具有显著效果。
